Effects of Clofibrate in the CB6F1-TgHras2 Mice
| Autor: | Tetsushi Dodo, Toshio Imai, Tomomi Ando, Kerns William D, Toyohiko Aoki, Kazuo Tsukidate, Satoru Motooka |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Nitrosourea
medicine.medical_specialty Clofibrate Peroxisome proliferator Positive control Hepatocellular adenoma Biology Toxicology medicine.disease Pathology and Forensic Medicine chemistry.chemical_compound Endocrinology chemistry Internal medicine Statistical significance medicine Bioassay Carcinogen medicine.drug |
| Zdroj: | Journal of Toxicologic Pathology. 15:111-118 |
| ISSN: | 1881-915X 0914-9198 |
| Popis: | The tumorigenic potential of clofibrate, a peroxisome proliferator, was evaluated in a 26-week bioassay using CB6F1-TgHras2 (rasH2) mice carrying a human prototype c-Ha-ras gene. Clofibrate was administered to rasH2 mice orally by gavage at doses of 0 (vehicle control), 125, 250 or 500 mg/kg/day for 26 weeks. Single i.p. injection of 75 mg/kg methyl nitrosourea (MNU) was given to additional rasH2 group as positive control. CB6F1 non-Tg-rasH2 (non-Tg) mice were given either vehicle or 500 mg/kg of clofibrate. In rasH2 mice receiving clofibrate, hepatocellular adenoma was observed in males; 0 (1/15), 125 (0/15), 250 (3/15), and 500 mg/kg (3/15), but not in females. Although the trend test was positive (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|