Structure-activity relationships of double-strand RGD peptides as GPIIb/IIIa receptor antogonists

Autor:	Barry S. Coller, Masakatsu Eguchi, Iwao Ojima, Clare M. Amann, Young-im Oh, Qing Dong
Rok vydání:	1994
Předmět:	Double strand Platelet aggregation Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry GpIIb/IIIa Drug Discovery Molecular Medicine Receptor Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 4:1749-1754
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)80374-1
Popis:	A series of new double-strand RGD peptides are synthesized and their inhibitory activities evaluated for platelet aggregation. Substantial improvement in activity is observed with these novel RGD peptides in comparison with single-strand RGD peptides. The structure-activity relationships of these double-strand RGD peptides are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6ea780f836bd48bdc1a6420e141f8c49 https://doi.org/10.1016/s0960-894x(00)80374-1 Zobrazit plný text záznamu