Nuclear track-etched filters as model pores for biological membranes

Autor:	M. Milovanovich, Donald T. Edmonds, G.M. Alder, P. Yu. Apel, N.I. Zhitariuk, A.A. Lev, C.A. Pasternak, G. Lowe, T.K. Rostovtseva, C. L. Bashford, Yuri E. Korchev, C.W. Pitt
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Scanning probe microscopy Radiation Membrane chemistry Proton Analytical chemistry Molecule Biological membrane Ion current Surface charge Instrumentation Divalent
Zdroj:	Radiation Measurements. 25:675-683
ISSN:	1350-4487
DOI:	10.1016/1350-4487(95)00220-9
Popis:	Ion current through individual pores in track-etched polyethyleneterephthalate filters can have the following properties which are shared by a number of biological ion channels: 1. 1) selectivity for cations over anions, or vice versa depending on the surface charge of the filter and the diameter of the pore; 2. 2) fluctuations between high- and low-conductance states; 3. 3) inhibition by protons and divalent cations with efficacy H + > Zn 2+ > Ca 2+ ∼ Mg 2+ . Pore topography in differing states can be imaged by scanning probe microscopy. We conclude that track-etched filters provide a useful model system for studying the physical and chemical basis for some of the characteristic behaviour of biological channels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6ea3aebe72194153d41efac356fa7297 https://doi.org/10.1016/1350-4487(95)00220-9 Zobrazit plný text záznamu Full Text from ScienceDirect