Association between circulating endothelial progenitor cells and hs-CRP in patients with diabetes
| Autor: | Megumi Koshikawa, Uichi Ikeda, Setsuo Kumazaki, Atsushi Izawa, Shigetaka Shimodaira, Jun Koyama, Takeshi Tomita |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
biology business.industry Vascular disease Endocrinology Diabetes and Metabolism C-reactive protein CD34 Inflammation medicine.disease Endothelial progenitor cell Pathogenesis Endocrinology Internal medicine Diabetes mellitus Immunology cardiovascular system Internal Medicine medicine biology.protein medicine.symptom Progenitor cell Cardiology and Cardiovascular Medicine business |
| Zdroj: | The British Journal of Diabetes & Vascular Disease. 10:133-138 |
| ISSN: | 1753-4305 1474-6514 |
| DOI: | 10.1177/1474651410365111 |
| Popis: | Aim Endothelial progenitor cells (EPCs) play a critical role in maintaining endothelial function and might affect the progression of vascular disease. This study investigated the relationship between circulating EPCs and high-sensitivity C-reactive protein (hs-CRP) in patients with diabetes. Methods Our study population comprised 190 consecutive patients, with and without diabetes. To obtain EPC numbers, CD34+ and CD133+ cells in peripheral blood were counted by flow cytometry. Results Significantly higher hs-CRP levels were observed in patients with diabetes than in those without diabetes. However, the number of EPCs was significantly lower in diabetic patients and in patients with high hs-CRP levels. Patients with diabetes and high hs-CRP levels showed a marked decrease in the number of EPCs compared with non-diabetic patients with low hs-CRP levels. Conclusion These results suggest that inflammation leads to decreased circulating EPCs in patients with diabetes, which might be related to the pathogenesis of diabetic vascular disease. |
| Databáze: | OpenAIRE |
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