Increased Leiden mutation and decreased serum levels of vitamin A and zeaxantin in patients with oesophageal, gastric, liver, pancreatic and colorectal cancers

Autor:	Alajos Pár, Gabriella Pár, Beáta Gasztonyi, Gyula Mózsik, Mária Figler, György Rumi
Rok vydání:	2004
Předmět:	Vitamin medicine.medical_specialty Mutation Lutein Cancer prevention biology business.industry Provitamin Gastroenterology Factor V Cancer medicine.disease medicine.disease_cause chemistry.chemical_compound chemistry Pancreatic cancer Internal medicine biology.protein Medicine business
Zdroj:	Zeitschrift für Gastroenterologie. 42
ISSN:	1439-7803 0044-2771
DOI:	10.1055/s-2004-826996
Popis:	Backgrounds: The increased prevalence of Leiden mutation (replacement of Arg by Glu of residue 506 in the factor V molecule, FVR, 506 Q) and the decrease serum levels of retinoids (vitamin A, zeaxantin, lutein, α- and s-carotene) have been proven in the patients in chronic bowel inflammatory diseases and colon polyposis (Mozsik et. al.: J. Physiol (Paris). 95: 488–494, 2001). Aim: was to study of changes in Leiden mutation and in serum levels of vitamin A and α- and s-carotene (α- and s-cryptoxantin, zeaxantin) inpatients with oesophageal (n=8), gastric (n=21), hepatocellular (n=15), pancreatic (n=10), and colorectal (n=44) cancers. Methods and patients: The Leiden mutation by PCR technique and serum levels of retinoids by HPLC were measured in the different gastrointestinal (oesophageal, gastric, hepatocellular, pancreatic and colorectal) cancer in comparison with 57 healthy person. Results: 1.) The prevalence of Leiden mutation increased significantly (21, 23, 21, 25, 35% vs. 5,5–6%; p values
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e9acad69b230347a451bb675de5089a https://doi.org/10.1055/s-2004-826996 Zobrazit plný text záznamu