Growth Inhibition of an Opportunistic Yeast Pathogen Trichosporon asahii by Staphylococcus epidermidis
| Autor: | Miki Nakajima, Hanari Yoshikawa, Kazuhiko Takatori, Kazuki Yanagisawa, Miho Watanabe, Yuki Ogasawara, Erika Okudaira, Tomoe Ichikawa, Kazuko Harigaya, Reiko Ikeda |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology biology Chemistry 030106 microbiology Pharmaceutical Science General Medicine Trichosporon asahii Fungal pathogen Trichosporonosis medicine.disease biology.organism_classification Yeast Microbiology Lactic acid 03 medical and health sciences chemistry.chemical_compound Staphylococcus epidermidis medicine Growth inhibition Pathogen |
| Zdroj: | Biological & Pharmaceutical Bulletin. 40:693-697 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b16-01000 |
| Popis: | In the co-culture of Staphylococcus epidermidis and Trichosporon asahii, a fungal pathogen, it was observed that live S. epidermidis inhibited the growth of T. asahii. Soluble active anti-T. asahii substances were speculated to be produced by S. epidermidis in culture medium. Using 1H- and 13C-NMR spectra and electron ionization-high resolution mass spectrometry (HR-negative-FAB-MS), we separated the active molecule and identified it as lactic acid. Commercially available L-lactic acid and D-lactic acid inhibited the growth of T. asahii. These results show that metabolites from bacterial populations are involved in the interactions of pathogenic fungi. The use of antibacterial agents to treat primary diseases could lead to the disruption of normal microbial communities and could cause opportunistic infections such as trichosporonosis. |
| Databáze: | OpenAIRE |
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