The mechanism of myocardial protection from ischemic arrest by intracoronary tetrodotoxin administration
| Autor: | John A. Waldhausen, James R. Neely, Todd Gj, G. Frank O. Tyers |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Pulmonary and Respiratory Medicine
Cardiac function curve Bradycardia Contraction (grammar) business.industry Bicarbonate Ischemia Creatine medicine.disease chemistry.chemical_compound chemistry Anesthesia medicine Tetrodotoxin Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Adenosine triphosphate |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 69:190-195 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)41580-8 |
| Popis: | Intracoronary injection of 14 meg. of tetrodotoxin into the ischemic isolated rat heart resulted in immediate cessation of mechanical activity. Upon reperfusion with oxygenated, modified Krebs-Henseleit bicarbonate buffer in a modified Langendorff apparatus, all hearts recovered normal rate, rhythm, and contractile vigor after up to 60 minutes of ischemia. In contrast, all hearts not administered tetrodotoxin showed bradycardia, irregular rhythm, and weak contraction upon reperfusion after 30 and 45 minutes of ischemia; after 60 minutes, no mechanical activity was evident. The improved cardiac function following ischemia in the tetrodotoxin-treated hearts was associated with persistence of normal adenosine triphosphate (ATP) levels after up to 30 minutes of ischemia and normal or elevated creatine phosphate (CP) levels after up to 60 minutes of ischemia. On the other hand, ATP and CP levels progressively declined to reach 50 per cent of normal values after 30 minutes in the ischemic hearts without tetrodotoxin. These findings indicate that postarrest A TP and CP levels play an important role in myocardial recovery after ischemic arrest. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|