Impaired Memory Formation and the Development of Transient Cholinergic Deficit in Mice after Olfactory Bulbectomy

Autor: N. A. Lazareva, O. A. Nedogreeva, M. Yu. Stepanichev, Natalia V. Gulyaeva
Rok vydání: 2021
Předmět:
Zdroj: Neuroscience and Behavioral Physiology. 51:748-756
ISSN: 1573-899X
0097-0549
Popis: Olfactory bulbectomy in rodents is widely used as a model of the symptoms of clinical depression and neurodegeneration, including cholinergic. Male C57BL/6 mice in the present study underwent olfactory bulbectomy. Formation of long-term nonassociative memory (habituation) and spatial memory were studied two and four weeks after surgery. The effect of bulbectomy on the state of neurons in the medial septal area was studied using immunohistochemical staining for choline acetyltransferase and NeuN at the end of the behavioral studies, i.e., four and seven weeks after surgery. Bulbectomy led to impaired habituation in terms of measures of motor activity in the open field test and impaired spatial learning, but not memory in a water maze at both time points. A decrease in the proportion of cholinergic cells in the medial septal area was seen at four but not seven weeks after surgery. There were no significant changes in the total number of neurons in this part of the brain. Thus, the occurrence of cognitive impairment after olfactory bulbectomy may be associated with the manifestations of transient cholinergic deficit at the early stages of the development of pathology.
Databáze: OpenAIRE
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