An Ocular Myopathy with Glycogen Storage and Abnormal Mitochondria in Muscle Fibres

Autor:	Bruno Rocchelli, Carla Marchetti, Roberto Scelsi, Luigi Faggi, Giorgio Sandrini
Rok vydání:	1981
Předmět:	Pathology medicine.medical_specialty Ocular myopathy Abnormal mitochondria Glycogen External ophthalmoplegia Anatomy Mitochondrion Biology medicine.disease chemistry.chemical_compound Neurology chemistry Mitochondrial myopathy Increased glycogen medicine Ultrastructure Neurology (clinical)
Zdroj:	European Neurology. 20:440-444
ISSN:	1421-9913 0014-3022
DOI:	10.1159/000115276
Popis:	The case of a 66-year-old woman with progressive external ophthalmoplegia and involvement of the proximal muscles of the upper and lower limbs is described. EMG examinations show signs of myopathic involvement. Histochemical and biochemical studies exclude a primary defect in glycogenosis. The authors stress the peculiarity of the histochemical findings, characterized by the rare associated appearance of both mitochondrial changes and glycogen accumulation in muscle fibres. The most prominent ultrastructural findings are evidence of increased glycogen, usually present in vescicles or in mitochondria, and changes in number, size and structure of mitochondria. Quantitative biochemical examination of muscle homogenates confirmed the increased content of glycogen in muscle fibres.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e6a9e23fa4185177b2d7611d588e31e https://doi.org/10.1159/000115276 Zobrazit plný text záznamu