Graphene-coated Ti-Nb-Ta-Mn foams: A promising approach towards a suitable biomaterial for bone replacement
| Autor: | Ricardo Chávez-Vásconez, Daniela Muñoz-Rojas, Mauricio Reyes-Valenzuela, Nicole Orellana, Juliet Aristizabal, Carolina Parra, Cristina Arévalo, Bárbara Arce, Sheila Lascano, Cristian A. Acevedo, Yadir Torres, Francisco J. Gotor |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Biocompatibility 02 engineering and technology 010402 general chemistry Bone tissue 01 natural sciences law.invention Bone replacement law Powder metallurgy Materials Chemistry medicine Cell adhesion Porosity Graphene technology industry and agriculture Biomaterial Surfaces and Interfaces General Chemistry equipment and supplies 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Surfaces Coatings and Films medicine.anatomical_structure Chemical engineering 0210 nano-technology |
| Zdroj: | Surface and Coatings Technology. 401:126250 |
| ISSN: | 0257-8972 |
| Popis: | The design of bone implants with proper biological and mechanical properties remains a challenge in medical implantology. The use of bioactive coatings has been shown to improve the biocompatibility of the implant surface. In this study, a new approach including porous scaffolds, β-Ti alloys and nanocoatings to design new bone implants is presented. Porous Ti-Nb-Ta-xMn alloys (x: 2, 4, and 6 wt%) substrates were obtained by powder metallurgy and the effect of the porosity and Mn content on mechanical properties was studied. CVD single-layer graphene was transferred onto the porous substrates that presented the best mechanical response (x: 4 wt%) for further evaluation of in vitro cell behavior (biocompatibility and cell adhesion). Cytotoxicity and biocompatibility tests confirmed that cell adhesion and proliferation were successfully achieved on graphene-coated porous substrates, confirming these systems are potential candidates for using in partial bone tissue replacement. |
| Databáze: | OpenAIRE |
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