Argyrophil Cell Microneoplasia in the Mastomys' Stomach-An Observation on Early Carcinoid Formation 2 3

Autor:	Hideo Kanahara, Kenji Tazawa, Takeshi Sakashita, Jun Soga, Morooka Hisashi, Kenzo Tajima, Tatsuro Kohro, Muneaki Sano, Karaki Yoshiaki
Rok vydání:	1975
Předmět:	Cancer Research Pathology medicine.medical_specialty Gradual transition biology Cell growth Stomach Cell Hyperplasia biology.organism_classification medicine.disease medicine.anatomical_structure Oncology Mastomys medicine
Zdroj:	JNCI: Journal of the National Cancer Institute. 55:1001-1006
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/55.4.1001
Popis:	To analyze the early stages of argyrophil cell carcinoid growth, complete serial sections were cut from the glandular portion of the stomachs of 22 Mastomys and submitted to Sevier-Munger's reaction. The 154 grossly invisible foci of argyrophil cell microproliferation thus detected were classified into three stages of microproliferations (I, II, and III), and the last stage was definitely a microcarcinoid. There was a gradual transition in cell proliferation among these three stages; the first stage (microproliferation I), in which the cells were morphologically indistinguishable from those of hyperplastic proliferation by general morphologic criteria, was where the initial change of argyrophil cell carcinoid formation was detectable by a light microscope. Whereas multiple occurrences of microcarcinoids accounted for the multiplicity of well-developed tumors in the stomachs of Mastomys, a well-developed carcinoid in this species was formed by the confluence of several microcarcinoids.
Databáze:	OpenAIRE
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