| Autor: |
P. Mayeux, Sylvie Gisselbrecht, C. Lacombe, N. Casadevall, Stany Chrétien, I. Dusanter |
| Rok vydání: |
1992 |
| Předmět: |
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| Zdroj: |
Pathophysiology and Pharmacology of Erythropoietin ISBN: 9783642770760 |
| Popis: |
The Friend virus complex consists of a replication competent virus, the Friend murine leukemia virus (F-MuLV) and a replication defective virus, the Friend spleen focus-forming virus (SFFV). The SFFV defective component is responsible for the induction of acute leukemia in adult mice of susceptible strains [1]. Erythroid cells infected with the polycythemiainducing variant of SFFV (SFFVp) can proliferate and differentiate in the absence of erythropoietin (Epo) whereas the anemia-inducing strain of SFFV renders them hypersensitive to the hormone. The envelope glycoprotein (Env) encoded by SFFV has been shown to be responsible for its biological effect [2].The majority of the SFFVp Env protein remains in the endoplasmic reticulum; however, a small part (3%-5%) is fully glycosylated and reaches the plasma membrane. This fraction transported to the cell surface seems to be essential for erythroblastosis [3,4]. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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