ChemInform Abstract: Threonine-Derived Phosphinite-Oxazoline Ligands for the Ir-Catalyzed Enantioselective Hydrogenation

Autor:	Andreas Pfaltz, Frederik Menges
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Phosphinite Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element General Medicine Oxazoline Iridium Threonine Enantiomer Medicinal chemistry Catalysis
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
Popis:	A series of chiral phosphinite-oxazolines was synthesized in four steps starting from carboxylic acids and threonine methyl ester. In the asymmetric hydrogenation of a number of alkenes, iridium complexes of these ligands induced significantly higher enantioselectivities than the corresponding serine-derived complexes. Enantiomeric excesses of 89 to 99% were obtained for unfunctionalized alkenes with turnover numbers of up to 5000.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e55793359ad872527cc2a6855a3c04b https://doi.org/10.1002/chin.200230027 Zobrazit plný text záznamu Plný text