ChemInform Abstract: Synthesis, Application and Scope of a New Protected Hydrazine Reagent

Autor:	Uno Mäeorg, Ulf Ragnarsson
Rok vydání:	2010
Předmět:	Acylation chemistry.chemical_compound Chemistry Reagent Hydrazine General Medicine Alkylation Combinatorial chemistry Hydrazine derivatives Catalysis
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
Popis:	A novel triprotected hydrazine reagent, 1,2-Boc2-2-Z-hydrazine (3),-has been made and investigated with respect to stepwise alkylation/acylation and intermediary deprotection in order to prepare multisubstituted hydrazine derivatives. Alkylation of 3 requires particularly mild basic conditions. Regiospecific cleavage of one Boc-group with acid in monoalkylated product 4 is difficult but can be accomplished with catalytic amounts of Mg(ClO4)2 in MeCN at 50 °C in 15 min, furnishing 5 which can easily be alkylated to 6. This product has recently been converted to fully substituted derivatives 7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e4da0e7035746cb9946907fb9e5f575 https://doi.org/10.1002/chin.199820094 Zobrazit plný text záznamu Plný text