Pre-resonance Raman and surface-enhanced Raman spectroscopy study of the complex of the antiviral and antiparkinsonian drug amantadine with histidine

Autor:	Jana Staničová, P. Miškovský, P. Kovalc̆ı́k, Laurent Chinsky
Rok vydání:	2001
Předmět:	Stereochemistry Chemistry Amantadine Antiparkinsonian Agent Surface-enhanced Raman spectroscopy Resonance (chemistry) symbols.namesake symbols medicine Molecule Binding site Raman spectroscopy Spectroscopy Histidine medicine.drug
Zdroj:	Vibrational Spectroscopy. 25:41-51
ISSN:	0924-2031
DOI:	10.1016/s0924-2031(00)00104-1
Popis:	UV-pre-resonance Raman spectroscopy (PRS) and surface-enhanced Raman spectroscopy (SERS) were applied to study the interaction of the antiviral and antiparkinsonian agent amantadine with histidine. The binding sites of amantadine and histidine molecules were identified in the complex. In this model, (i) the amino group of amantadine and the N1H group of histidine are included in the complex formation, (ii) the creation of the complex is mediated via formation of an H-bond between the nitrogen of the amantadine amino group and the hydrogen of the histidine N1H group. This model of the amantadine–histidine complex formation is discussed in the relation to a possible mode of interaction of the M2 protein transmembrane region with amantadine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e4d81dfef15fd8d4471084669c56be6 https://doi.org/10.1016/s0924-2031(00)00104-1 Zobrazit plný text záznamu Full Text from ScienceDirect