Covalent versus Noncovalent Binding of Ruthenium η 6 ‐ p ‐Cymene Complexes to Zinc‐Finger Protein NCp7
| Autor: | Zhuanghao Hou, Siming Yuan, Jakob Kljun, Kaiming Cao, Yangzhong Liu, Shiyong Cui, Mei Sun, Guangming Huang, Iztok Turel, Yaping Sheng |
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| Rok vydání: | 2019 |
| Předmět: |
Zinc finger
chemistry.chemical_classification Reaction mechanism p-Cymene 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Ruthenium chemistry.chemical_compound Covalent bond Non-covalent interactions Reactivity (chemistry) Group 2 organometallic chemistry |
| Zdroj: | Chemistry – A European Journal. 25:12789-12794 |
| ISSN: | 1521-3765 0947-6539 |
| Popis: | Ruthenium-arene complexes are a unique class of organometallic compounds that have been shown to have prominent therapeutic potencies. Here, we have investigated the interactions of Ru-cymene complexes with a zinc-finger protein NCp7, aiming to understand the effects of various ligands on the reaction. Five different binding modes were observed on selected Ru-complexes. Ru-cymene complex can bind to proteins through either noncovalent binding alone or through a combination of covalent and noncovalent binding modes. Moreover, the noncovalent interaction can promote the coordination of RuII to NCp7, resulting synergistic effects of the different ligands. The binding of Ru(Cym) complexes leads to dysfunction of NCp7 through zinc-ejection and structural perturbation. These results indicate that the reactivity of Ru-complexes can be modulated by ligands through different approaches, which could be closely correlated to their different therapeutic effects. |
| Databáze: | OpenAIRE |
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