Are There Specific Cancer Stem Cell Markers?

Autor:	Linxiang Lan, Axel Behrens
Rok vydání:	2023
Předmět:	Cancer Research Oncology
Zdroj:	Cancer Research. 83:170-172
ISSN:	1538-7445 0008-5472
DOI:	10.1158/0008-5472.can-22-2053
Popis:	The cancer stem cell (CSC) model states that heterogeneous tumor cell populations are organized in a hierarchical manner, with a small population of CSCs at the apex. These CSCs are capable of self-renewal and giving rise to other cancer cell populations, conceptually analogous to the function of normal adult stem cells present in almost all organs. However, there has been significant controversy regarding the existence and identification of CSCs. We argue that technical differences in experimentation and CSC assays, CSC niche-dependency and plasticity, and CSC heterogeneity itself may explain some of the differences observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e2b741de3cacb6c3a0e9e80b5323a22 https://doi.org/10.1158/0008-5472.can-22-2053 Zobrazit plný text záznamu