Biologic Effects of Nitrous Oxide
| Autor: | Robert D. Sanders, Jörg Weimann, Mervyn Maze, David S. Warner, Mark A. Warner |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
inorganic chemicals
business.industry organic chemicals Context (language use) Nitrous oxide equipment and supplies Clinical Practice chemistry.chemical_compound Anesthesiology and Pain Medicine chemistry Neurocognitive Dysfunction Anesthesia Anesthetic medicine bacteria Occupational exposure Adverse effect business medicine.drug |
| Zdroj: | Anesthesiology. 109:707-722 |
| ISSN: | 0003-3022 |
| Popis: | Nitrous oxide is the longest serving member of the anesthesiologist’s pharmacologic armamentarium but remains a source of controversy because of fears over its adverse effects. Recently, the Evaluation of Nitrous oxide In a Gas Mixture for Anaesthesia (ENIGMA) trial reported that nitrous oxide use increases postoperative complications; further preclinical reports have suggested that nitrous oxide may contribute to neurocognitive dysfunction in the young and elderly. Therefore, nitrous oxide’s longevity in anesthetic practice is under threat. In this article, the authors discuss the evidence for the putative toxicity of nitrous oxide, from either patient or occupational exposure, within the context of the mechanism of nitrous oxide’s action. Although it would seem prudent to avoid nitrous oxide in certain vulnerable populations, current evidence in support of a more widespread proscription from clinical practice is unconvincing. NITROUS oxide has been used in clinical anesthetic practice for more than 150 yr, and its longevity should be considered within the context of all the major advances in anesthetic practice over that time. Fifty years ago, concerns were expressed about nitrous oxide’s toxicity after anesthesia. 1 This report was followed 10 yr later with concerns |
| Databáze: | OpenAIRE |
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