Local bivalve allergens — a Malaysian perspective
| Autor: | M. Rosmilah, Syakirah Samsudin, Faizal Bakhtiar, Noormalin Abdullah, Zailatul Hani Mohamad Yadzir |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Gel electrophoresis
Allergy 030231 tropical medicine Biology Arginine kinase medicine.disease medicine.disease_cause Immunoglobulin E Tropomyosin Microbiology 03 medical and health sciences 0302 clinical medicine Allergen 030228 respiratory system medicine biology.protein Immunology and Allergy Polyacrylamide gel electrophoresis Shellfish |
| Zdroj: | Allergo Journal. 27:32-37 |
| ISSN: | 2195-6405 0941-8849 |
| DOI: | 10.1007/s15007-018-1721-9 |
| Popis: | Apart from the nutritional benefits, bivalves are also considered to be among a group of allergenic foods. Symptoms of allergy to bivalves are largely similar to those of allergic reactions reported for other shellfish. The identification of allergenic proteins in a particular species is an important step for the development of more accurate allergy tests and for the definition of more effective management of patients. Currently, studies regarding the allergens in bivalve species are lacking. This minireview is an overview of local scientific articles on identification of bivalve allergens by allergenomics methods including sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional gel electrophoresis (2-DE), immunoblotting and mass-spectrometry analysis. Tropomyosin has been the only well recognized allergen in a wide range of bivalve species. In addition to tropomyosin, our local study resulted in discovery of three novel bivalve major allergens; arginine kinase (40 kDa), actin (42 kDa) and troponin C (18 kDa). This minireview will provide a better understanding of each allergen derived from local bivalves which subsequently will help in the understanding of the specific immunoglobulin E(IgE)-mediated immune response. |
| Databáze: | OpenAIRE |
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