Isolation, Identification, and Decomposition of Antibacterial Dialkylresorcinols from a Chinese Pseudomonas aurantiaca Strain
| Autor: | Yue Shi, Benjamin R. Clark, Diana A. Zaleta-Pinet |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
biology Strain (chemistry) 010405 organic chemistry Stereochemistry Chemistry Metabolite Organic Chemistry Pharmaceutical Science Nuclear magnetic resonance spectroscopy Tandem mass spectrometry biology.organism_classification 01 natural sciences Benzoquinone 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Drug Discovery Pseudomonas aurantiaca Molecular Medicine Antibacterial activity Hydroxyquinone |
| Zdroj: | Journal of Natural Products. 83:194-201 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00315 |
| Popis: | A chemical investigation of a Chinese Pseudomonas aurantiaca strain has yielded a new benzoquinone (4) and furanone (5), in addition to the known dialkylresorcinols 1 and 2. Extensive decomposition studies on the major metabolite 1 produced an additional furanone derivative (6), a hydroxyquinone (7), and two unusual resorcinol and hydroxyquinone dimers (8 and 9). Structures were elucidated by nuclear magnetic resonance spectroscopy in combination with tandem mass spectrometry analysis. These studies illustrate the potential of artifacts as a source of additional chemical diversity. Compounds 1 and 2 showed moderate antibacterial activity against a panel of Gram-positive pathogens, while the antibacterial activities of the artifacts (4–9) were reduced. |
| Databáze: | OpenAIRE |
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