Genetic variants of the nuclear factor erythroid 2-related factor 2/antioxidant reaction element pathway on the risk of antituberculosis drug-induced liver injury: a systematic review

Autor:	Zhuolu Hao, Meiling Zhang, Xinyu Chen, Min Zhu, Bing Han, Yiwen He, Honggang Yi, Shaowen Tang
Rok vydání:	2023
Předmět:	Pharmacology Genetics Molecular Medicine
Zdroj:	Pharmacogenomics.
ISSN:	1744-8042 1462-2416
DOI:	10.2217/pgs-2023-0040
Popis:	Aim: To evaluate the effects of genetic variants in the nuclear factor erythroid 2-related factor 2/antioxidant reaction element signaling pathway on antituberculosis drug-induced liver injury (AT-DILI) susceptibility. Methods: The PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure and Wanfang databases were searched from inception to April 2022. Results: Seven case–control studies with 4676 patients were included. Six genes with 35 SNPs in the pathway have been reported. Among 17 SNPs reported in two or more studies, the meta-analysis indicated that only one SNP (rs3735656 in MAFK) was significantly associated with a decreased risk for AT-DILI under the dominant model (odds ratio: 0.636; 95% CI: 0.519–0.780; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6e0c9aeed19e75e1012dffa3f49f5192 https://doi.org/10.2217/pgs-2023-0040 Zobrazit plný text záznamu