The influence of radiation sterilisation on some β-blockers in the solid state

Autor: Magdalena Hofman, M. Ogrodowczyk, B. Czajka, Barbara Marciniec
Rok vydání: 2011
Předmět:
Zdroj: Thermochimica Acta. 514:10-15
ISSN: 0040-6031
DOI: 10.1016/j.tca.2010.11.024
Popis: Six derivatives of aryloxyalkylaminopropanol of known β-adrenolytic activity (acebutolol, alprenolol, atenolol, metoprolol, pindolol, propranolol) in solid phase were exposed to the ionising radiation generated by e-beam of high-energy electrons from an accelerator (∼10 MeV) in doses from 25 to 400 kGy. To establish the effects of irradiation on their physico-chemical properties, the compounds were then analysed by differential scanning calorimetry (DSC), scanning electron microscope (SEM), X-ray diffraction (XRD) and FT-IR spectrometry. The standard sterilisation dose (25 kGy) was found to cause no changes in only one derivative – acebutolol, whereas in the other derivatives the irradiation caused colour changes, differences in X-ray diffraction patterns and in the character of DSC curves, including a decrease in the melting point. For each derivative one clear peak corresponding to the process of melting was observed and its position shifted towards lower temperatures with increasing dose of irradiation. For all compounds studied the value of the shift was between 0.1 and 1.0 °C. For alprenolol, propranolol and metoprolol linear relations were found between the irradiation dose and the decrease in the melting point, described by the correlation coefficient (between 0.9446 and 0.9864). No changes were observed in the FT-IR spectra and in the SEM images of the compounds studied.
Databáze: OpenAIRE
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