Effect of Buffalo Milk on Rat’s Lung Exposed to Noise
| Autor: | Massumeh Ahmadizadeh, Zohre Jafarzadeh, Jamshid Alizadeh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
021110 strategic
defence & security studies Lung Adult male business.industry 0211 other engineering and technologies Physiology Sodium pentobarbital 02 engineering and technology Glutathione 010501 environmental sciences Malondialdehyde 01 natural sciences Noise chemistry.chemical_compound Noise exposure medicine.anatomical_structure chemistry Toxicity Medicine business 0105 earth and related environmental sciences |
| Zdroj: | Jundishapur Journal of Health Sciences. 11 |
| ISSN: | 2252-0627 2252-021X |
| Popis: | Background: Noise is known as annoying sound that can cause damage in auditory and non-auditory systems in humans and animals. The role of diet in reducing the toxicity of xenobiotics has been growing. Milk has found as one of the nutrients with protective effects against the toxic effects of many chemicals. Objectives: The aim of the present study was to investigate the impact of buffalo’s milk (BM) on noise-related injury in rat lung. Methods: Twenty adult male Wistar rats weighing 200 - 250 g were provided and kept under standard conditions. The rats were randomly divided into four groups (n = 5). Group one was selected as the control group (without administration of buffalo’s milk (BM) and no noise exposure). The second group was given BM (1 mL/d) and exposed to 100 dB noise for four hours daily within two consecutive weeks. The animals of third group were exposed to 100 dB noise for four h daily through two consecutive weeks and the rats of the forth group were treated with BM (1 mL/d) daily for two consecutive weeks (without noise exposure). Twenty-four hours after the last treatment, all animals were killed with overdose of sodium pentobarbital. The lung tissues were removed and processed for malondialdeyde (MDA) and glutathione (GSH) biochemical tests and histopathological observations. Results: Noise exposure increased the level of MDA and reduced GSH level in animals compared to those in the unexposed (control) group. Exposure to noise also caused morphological modification in rat lung. BM did not alter biochemical and histopathological parameters in rat lung compared to the control rats. However, BM significantly decreased MDA and increased GSH levels and caused no obvious damage in the animals exposed to noise. Conclusions: The results of the present study indicated that noise caused damage in the rat lung and BM protected lung cells against the noise-induced toxicity. |
| Databáze: | OpenAIRE |
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