Inositol Lipids and Phosphates in the Proliferation and Differentiation of Lymphocytes and Myeloid Cells
| Autor: | Robert H. Michell, Louise A. Conroy, Michael Finney, Philip J. French, Christopher M. Bunce, Kim Anderson, Michael A. Baxter, Geoffrey Brown, John Gordon, Eric J. Jenkinson, Janet M. Lord, Christopher J. Kirk, John J. T. Owen |
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| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Ciba Foundation Symposium 164-Interactions Among Cell Signalling Systems ISBN: 9780470514207 Ciba Foundation Symposium 164-Interactions Among Cell Signalling Systems |
| Popis: | It is established that receptor-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate is an essential signalling reaction in the responses of many haemopoietic cells to stimuli: examples include platelet activation, antigen-driven initiation of cell proliferation in mature B and T lymphocytes and histamine release by mast cells, and chemotaxis and oxygen radical generation by neutrophils. However, the roles of inositol lipids and phosphates in the development of haemopoietic and immune cells are less well understood. This paper discusses three such situations: the sequential employment of phosphatidylinositol 4,5-bisphosphate hydrolysis and cyclic AMP accumulation as two signals essential to the action of the B lymphocyte-stimulatory cytokine interleukin 4; the involvement of antigen receptor-triggered inositol lipid hydrolysis in apoptotic elimination of immature anti-self T lymphocytes in the fetal mouse thymus; and the possible role of changes in the levels of abundant inositol polyphosphates in the differentiation of HL-60 promyelocytic cells and of normal human myeloid blast cells. |
| Databáze: | OpenAIRE |
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