Ultrastructural study of magnesium dependent adenosine triphosphatase (Mg-ATPase) activity in rat liver peroxisomes after administration of aspirin and clofibrate
| Autor: | Kazuo Hakoi, Kenji Irimura, Takashi Makita |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Aspirin Adenosine triphosphatase Clofibrate Magnesium chemistry.chemical_element General Medicine Mitochondrion Biology Peroxisome Molecular medicine Pathology and Forensic Medicine Endocrinology chemistry Internal medicine medicine Ultrastructure Anatomy Molecular Biology medicine.drug |
| Zdroj: | Medical Electron Microscopy. 26:161-168 |
| ISSN: | 1860-1499 0918-4287 |
| DOI: | 10.1007/bf02347995 |
| Popis: | A total of 36 male F344 rats was fed a diet containing 1% aspirin or 0.25% clofibrate for 1, 3 and 4 weeks. Hepatomegaly was more evident with aspirin than with clofibrate. The activity of magnesium dependent adenosine triphosphatase (Mg-ATPase) was localized on the limiting membrane of aspirin-induced peroxisomes, but it was much weaker than that in control and clofibrate-induced peroxisomes. Alteration in the ultrastructure of peroxisomes and mitochondria became more evident in Week 4 of the experiment than in Week 1. These ultrastructural changes also basically returned to normal conditions after one week withdrawal of the chemicals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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