Induction of amyloid arthropathy in chickens

Autor:	Wil J.M. Landman, Paul A.P. Crauwels, Claartje A.M. Koch, Erik Gruys, Peter C.J. Tooten, Nicolaas H.M.T. Peperkamp
Rok vydání:	1997
Předmět:	Pathology medicine.medical_specialty Future studies Amyloid business.industry Amyloidosis Arthritis Single injection medicine.disease Amyloid arthropathy Pathogenesis mental disorders Immunology Internal Medicine medicine business Articular amyloid
Zdroj:	Amyloid. 4:87-97
ISSN:	1744-2818 1350-6129
DOI:	10.3109/13506129708995276
Popis:	The present report describes a novel chicken model in which reactive (AA) joint amyloidosis arises ajier a single injection of Enterococcus faecalis isolated from jield outbreaks of reactive amyloid arthropathy in domestic fowl. All six week old brown layer pullets injected intravenously with 109 or 109 colony forming units developed reactive amyloid arthropathy. Amyloid masses were also present in internal organs. The first articular amyloid deposits were observed 5 days after injection. in internal organs, deposits were encountered fiom day 13 onwards. on intra-articular injection, amyloid arthropathy developed particularly in Ihe target joint and in the internal organs.This model ofAA amyloid arthropathy may contribute in future studies to unravel the pathogenesis of the tissue predilection of amyloid deposition and 05 amyloid arthropathy in general.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6df170ea30837a6511be3e9ec5db4ee1 https://doi.org/10.3109/13506129708995276 Zobrazit plný text záznamu