Effect of glycemic control on nocturnal arterial oxygen saturation: A case‐control study in type 2 diabetic patients 血糖控制对夜间动脉血氧饱和度的影响：一项2型糖尿病患者的病例对照研究

Autor:	Gabriel Sampol, Silvia Valladares, Andreea Ciudin, Cristina Hernández, Albert Lecube, Rafael Simó
Rok vydání:	2014
Předmět:	medicine.medical_specialty Endocrinology business.industry Endocrinology Diabetes and Metabolism Internal medicine Diabetes mellitus Case-control study Cardiology Medicine Nocturnal business medicine.disease Glycemic
Zdroj:	Journal of Diabetes. 7:133-138
ISSN:	1753-0407 1753-0393
DOI:	10.1111/1753-0407.12197
Popis:	Background There is growing evidence suggesting a deleterious effect of type 2 diabetes on lung function and sleep breathing. The aim of this case-control study was to evaluate whether or not an improvement in glycemic control could arrest or ameliorate nocturnal hypoxemia in type 2 diabetes. Methods Thirty patients with type 2 diabetes with HbA1c ≥8% (cases) and 10 non-diabetic subjects were analyzed. Controls were closely matched to cases by age, gender, body mass index, and neck circumference. The nocturnal oxygen desaturation index (ODI) was calculated at baseline and 5 days after blood glucose improvement with pharmacological intervention. Four different oxygen desaturation thresholds (reductions in SaO2 ≥ 3%, 4%, 6%, and 8%) as indicators of hypoxemia severity (ODI-3%, ODI-4%, ODI-6%, ODI-8%) were used. Results At baseline, patients with diabetes showed a higher number of ODI-3%, ODI-4%, and ODI-6% in comparison with controls. A significant reduction in ODI-3% (29.7 [4.8–107.9] events per hour at baseline versus 24.6 [3.1–97.7] e/h at discharge, P
Databáze:	OpenAIRE
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