METHYL-β-CYCLODEXTRIN ASSISTED ENANTIOSELECTIVE ESTER HYDROLYSIS CATALYZED BY LIPASE IMMOBILIZED IN A POLYMER MEMBRANE
| Autor: | Józef Ceynowa, Izabela Koter |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Cyclodextrin Membrane reactor biology Process Chemistry and Technology General Chemical Engineering Filtration and Separation Alcohol General Chemistry Catalysis Kinetic resolution chemistry.chemical_compound Membrane chemistry biology.protein Organic chemistry Lipase Enantiomer |
| Zdroj: | Separation Science and Technology. 36:2885-2898 |
| ISSN: | 1520-5754 0149-6395 |
| DOI: | 10.1081/ss-100107635 |
| Popis: | Kinetic resolution of racemates by means of enzyme processes occurring in a membrane reactor is discussed. The reactor containing a lipase catalyst immobilized within the polyamide membrane was used to separate (R,S)-1-phenylethanol and (R,S)-1-phenyl-1-propanol that were produced by ester hydrolysis. The efficient separation was accomplished by the on-line extraction of the produced alcohols in an independent membrane extraction module. Methyl-β-cyclodextrin was used as an alcohol extractant to separate alcohols from both the unreacted esters and the produced acids. Thermal decomposition (at 60–70°C) of the formed complexes of methyl-β-cyclodextrin and alcohol is suggested as a convenient method for reextraction. Application of the hybrid reactor-extractor membrane system yielded higher reaction rates and greater enantiomer excess in relation to the unreacted R–ester. |
| Databáze: | OpenAIRE |
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