ChemInform Abstract: Synthesis of 4-Phenylpiperidines by Tandem Wittig Olefination-Aza- Wittig Rearrangement of 2-Benzoylaziridines
| Autor: | Alan John Collis, Iain Coldham, Richard E. Rathmell, Roger J. Mould |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | ChemInform. 27 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.199609148 |
| Popis: | A number of routes to 2-vinylaziridines are reported. N-Alkylation of a range of 2-benzoyl-3-alkylaziridines with tert-butyl bromoacetate followed by Wittig olefination gave directly a range of 4-phenylpiperidines. The intermediate 2-vinylaziridines rearrange by a [2,3]-aza-Wittig rearrangement to give the 4-phenylpiperidines. |
| Databáze: | OpenAIRE |
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