New quinoline- and isoquinoline-based multicomponent methods for the synthesis of 1,1(3,3)-dicyanotetrahydrobenzoindolizines

Autor:	I. A. Sanin, A. A. Zubarev, A. Yu. Rudenko, Lyudmila A. Rodinovskaya, E. A. Batuev, A. M. Shestopalov
Rok vydání:	2018
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Quinoline Condensation Organic chemistry Stereoselectivity General Chemistry Isoquinoline 010402 general chemistry 01 natural sciences 0104 chemical sciences Malononitrile
Zdroj:	Russian Chemical Bulletin. 67:297-303
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-018-2073-z
Popis:	Convenient multicomponent methods for the synthesis of benzannulated dihydroindolizines based on quinoline or isoquinoline, malononitrile, aromatic aldehydes and α-halomethylcarbonyl compounds were developed. Several alternative protocols of using the reactants were studied, starting with separate generation of two most probable intermediates and ending with the four-component condensation of all reactants. The scope of applicability of these methods was found, depending on the initial compounds used. The reaction is highly stereoselective with predominant formation of one of the possible isomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6dc4d4a91a61c415fe4242daaba528fa https://doi.org/10.1007/s11172-018-2073-z Zobrazit plný text záznamu Full text from SpringerLink