Balancing gene transfection and cytotoxicity of nucleic acid carriers with focus on ocular and hepatic disorders: evaluation of hydrophobic and hydrophilic polyethyleneimine derivatives

Autor:	Fernando A. de Oliveira, Lindomar J. C. Albuquerque, Michelle Nascimento-Sales, Marcelo A. Christoffolete, Ismael C. Bellettini, Fernando C. Giacomelli
Rok vydání:	2023
Předmět:	Biomedical Engineering General Materials Science General Chemistry General Medicine
Zdroj:	Journal of Materials Chemistry B. 11:4556-4571
ISSN:	2050-7518 2050-750X
Popis:	This investigation highlights that ocular and hepatic gene delivery can be potentialized by using small hydrophobic moieties along with lactose domains, and principally, succinic acid conjugated to polyethylenimine chains.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6dbb0d534457c1c721e7bc9c8141efe3 https://doi.org/10.1039/d3tb00477e Zobrazit plný text záznamu