Predictors of Mortality in Patients with Chronic Heart Failure: Is Hyponatremia a Useful Clinical Biomarker?
| Autor: | Manal M Alem |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Ejection fraction business.industry Renal function Retrospective cohort study General Medicine 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine Interquartile range 030220 oncology & carcinogenesis Internal medicine Heart failure Clinical endpoint Cardiology Medicine business Hyponatremia Survival analysis |
| Zdroj: | International Journal of General Medicine. 13:407-417 |
| ISSN: | 1178-7074 |
| DOI: | 10.2147/ijgm.s260256 |
| Popis: | Background Chronic heart failure (CHF) is a global health burden. Despite advances in treatment, there remain well-recognised morbidity and mortality. Risk stratification requires the identification and validation of biomarkers, old and new. Hyponatremia has re-emerged as a prognostic marker in CHF patients. Methods This is a retrospective cohort study on 241 CHF patients recruited from King Fahd Hospital of the University, Al-Khobar, Saudi Arabia (January 2005-December 2016). Their serum sodium and biochemical parameters were measured at baseline, along with 2-D echocardiographic assessments of left ventricular mass and ejection fraction. The primary endpoint was the association between hyponatremia and all-cause mortality (ACM) after a follow-up period of 24 months. Results Mean age of patients was 60.61 ± 12.63 (SD) years; 65.1% were males, and type 2 diabetes mellitus (DM) was present in 71%. Baseline serum sodium was 138.00 (136, 140) (median and interquartile range). Hyponatremia ( |
| Databáze: | OpenAIRE |
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