Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis*
| Autor: | Cris G. dos Remedios, David S. Celermajer, Johan Duflou, Wendy M. Mak, Clive Woolfe, Ghassan J. Maghzal, Roland Stocker, Val Gebski, Dorrilyn Rajbhandari, Yutang Wang, Dechaboon Changsirivathanathamrong |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
business.industry Tryptophan Pharmacology Tryptophan Metabolism Critical Care and Intensive Care Medicine medicine.disease Vascular tone Sepsis chemistry.chemical_compound Enzyme Biochemistry chemistry Shock (circulatory) medicine medicine.symptom business Kynurenine |
| Zdroj: | Critical Care Medicine. 39:2678-2683 |
| ISSN: | 0090-3493 |
| DOI: | 10.1097/ccm.0b013e31822827f2 |
| Popis: | Objectives:To determine whether tryptophan metabolism to kynurenine contributes to the direct regulation of vascular tone in human septic shock.Background:Indoleamine 2,3-dioxygenase 1 is an inducible enzyme that converts tryptophan to kynurenine and shares functional similarities with inducible nit |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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