Bioanalysis of organophosphate nerve agents in soil samples
| Autor: | T.W. Sawyer, M.T. Weiss |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Bioanalysis
Environmental Engineering Soil test Health Toxicology and Mutagenesis Organophosphate Public Health Environmental and Occupational Health General Medicine General Chemistry Contamination Pollution chemistry.chemical_compound chemistry Environmental chemistry medicine Environmental Chemistry Bioassay Nerve agent medicine.drug |
| Zdroj: | Chemosphere. 26:2023-2029 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(93)90028-4 |
| Popis: | Four soil samples that may have been spiked with chemical warfare (CW) agents and their degradation products were received by Defence Research Establishment Suffield as part of a multinational round-robin exercise designed to evaluate laboratory methodologies for the chemical detection of CW agents in soil. After chemical analysis revealed that VX (ethyl S-2-diisopropyl aminoethyl methylphosphorothiolate) was the CW agent “spike”, the samples were also bioassayed for their VX content by assessing their anticholinesterase activities in primary chick embryo neuron cultures. Bioassay quantitation of VX contamination in the soil samples was in good agreement with the actual spike levels and generally better than the chemical analytical results. Sequential bioassay of the samples over a two week period showed that the VX content was rapidly degraded with time. This assay complements standard chemical analytical techniques for the detection and verification of organophosphate warfare agent use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|