Chemical constituents from Schisandra perulata and their cytotoxic activity
| Autor: | Tran Tuan Anh, Vu Van Doan, Vu Thi Xuan, Bui Quang Tuan, Bui Huu Tai, Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen The Cuong, SeonJu Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Nguyen Thi Mai |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biology
010405 organic chemistry Positive control Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Cell culture Reagent Chemical constituents Cytotoxic T cell Agronomy and Crop Science IC50 Tetrahydrofuran Biotechnology Nuclear chemistry Schisandra |
| Zdroj: | Phytochemistry Letters. 41:65-69 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2020.11.002 |
| Popis: | Two new compounds, schisandrulata A (1) and schisandrulata B (5), and nine known compounds, 6-O-benzoylgomisin O (2), kadsutherin (3), γ-schizandrin (4), pinotatol (6), schisphentetralone A (7), (–)-8′-epi-aristotetralone (8), (–)-8,8′-epi-aristotetralone (9), rel-(8R,8′R)-dimethyl-(7S,7′R)-bis(3,4-methylenedioxyphenyl)tetrahydrofuran (10) and (-)-machilusin (11) were isolated from the leaves of Schisandra perulata Gagnep. Their chemical structures were determined by means of HR-ESI-MS, NMR, and CD spectra. All the compounds were evaluated for their cytotoxic activity against the human oral cancer (CAL27) and human breast cancer (MDA-MB231) cell lines. Compounds 1, 4, 7, and 9 showed potent cytotoxic activity against CAL27 cell line with IC50 values of 1.8 ± 0.2, 1.2 ± 0.1, 1.2 ± 0.2, and 2.0 ± 0.1 μM, respectively, indicating that they have stronger cytotoxic activity than that of the positive control capecitabine (IC50 value of 8.20 ± 0.75 μM). Similarly, compounds 1, 4, 7, and 9 also exhibited potent activity against the MDA-MB231 cell line with IC50 values of 3.5 ± 0.1, 1.80 ± 0.2, 0.9 ± 0.2, and 3.4 ± 0.3 μM, respectively. These results indicated that compounds 1, 4, 7, and 9 could be potential anticancer reagents for further drug discovery research. |
| Databáze: | OpenAIRE |
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