PP213 DETERMINATION OF PLASMATIC LEVELS OF VITAMIN A, E, C, B12 AND FOLIC ACID IN EACH STAGE OF COLORECTAL CANCER

Autor: D. Solichova, Zdenek Zadak, Alena Ticha, Radomír Hyšpler, Miloslav Hronek
Rok vydání: 2010
Předmět:
Zdroj: Clinical Nutrition Supplements. 5:106
ISSN: 1744-1161
DOI: 10.1016/s1744-1161(10)70288-x
Popis: Rationale: The aim of this study was to determine plasmatic levels of vitamins A, E, C B12 and folic acid that may be involved in the antioxidative activity process in cancerogenesis in patients with colorectal cancer (CCa) utilizable for nutritional support. Methods: Plasmatic levels of vitamins with antioxidative activity in two cohorts were determined. In the first group, nineteen men and eleven women in age 64±12 y with confirmed colorectal cancer, before treatment, were observed. 4 patients were in stage Dukes A, 16 patients in Dukes B, 5 patients in Dukes C and 4 patients in Dukes D. In the control cohort nineteen men and eleven women with benign disorders, such as inguinal hernia or varices without inflammatory responses were examined. Results: In all stages Dukes of CCa plasmatic levels of vitamin A were significantly lower than in control subjects (P =0.016). In stage Dukes A no statistical difference between the two cohorts was found. Significant differences in plasmatic levels by unpaired t-test were observed between lower plasmatic level in Dukes B of vitamin A (1.84±0.18mmol/l) versus the control group (2.26±0.12mmol/l), vitamin E (20.53±2.03mmol/l versus 25.83±1.09mmol/l); in Dukes C of vitamin C (25.83±1.09mmol/l versus 36.96±5.27mmol/l); in Dukes D of vitamin A (1.48±0.43mmol/l versus (2.26±0.12mmol/l). Conclusion: In the pilot study we have proved there are lower plasmatic levels of some vitamines with antioxidative activity in each stage of CCa. In regards of this deficit, to think about vitamins perorals or parenteral supplementation as part and parcel of nutritive support is important. Disclosure of Interest: None declared
Databáze: OpenAIRE
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