Anti-Initiating Activity of 3β-Methoxy-13α,14α-epoxyserratan-21β-ol (PJJ-34) from the Stem Bark ofPicea jezoensisCarr. var.jezoensis
| Autor: | Harukuni Tokuda, Toshifumi Minami, Reiko Tanaka |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Stem bark
integumentary system biology Chemistry Test group Bioengineering General Chemistry General Medicine Pharmacology biology.organism_classification Biochemistry Triterpenoid Oral administration In vivo Botany Ultraviolet light Molecular Medicine Molecular Biology Picea jezoensis Tumor multiplicity |
| Zdroj: | Chemistry & Biodiversity. 3:818-824 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.200690084 |
| Popis: | Ultraviolet light is the major cause of skin cancers in human, and several effects of ultraviolet light B (UVB) are thought to contribute to skin photocarcinogenesis. 3Beta-methoxy-13alpha,14alpha-epoxyserratan-21beta-ol (PJJ-34; 1) isolated from Picea jezoensis Carr. var. jezoensis showed the strongest antitumor-promoting activity among naturally occurring triterpenoids in the in vivo two-stage mouse skin-carcinogenesis test. To investigate the anti-initiating activity, we further studied mouse models initiated with ultraviolet-B (UVB) and promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA). Oral administration of the PJJ-34 (1) during a period before and after the three times of UVB irradiation led to a remarkable effect: oral administration of a 0.0025% solution of 1 only to the test group, which started one week before and ended one week after the irradiation, showed less than half papillomas, and inhibition of tumor incidence and tumor multiplicity in comparison to the control group. Therefore, it was recognized that PJJ-34 (1) showed strong anti-initiating activity as well as anti-promoting activity. After all, 1 seems to be useful as cancer-chemopreventive agent. |
| Databáze: | OpenAIRE |
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