Clinical characteristics of children affected by autism spectrum disorder with and without generalized hypotonia

Autor:	Mauricio A. López-Espejo, Alicia C. Nuñez, Odalie C. Moscoso, Raul G. Escobar
Rok vydání:	2021
Předmět:	Pediatrics medicine.medical_specialty Muscle Hypotonia business.industry Generalized hypotonia Motor Stereotypies medicine.disease Hypotonia Autism Diagnostic Observation Schedule Independent walking Quality of life Autism spectrum disorder Pediatrics Perinatology and Child Health medicine medicine.symptom business
Zdroj:	European Journal of Pediatrics. 180:3243-3246
ISSN:	1432-1076 0340-6199
Popis:	In this cross-sectional study, we aimed to evaluate the association between generalized hypotonia (GH) and demographic features and clinical characteristics in toddlers (2 to 5 years) with autism spectrum disorder (ASD). Among 93 children, 32 (34.4%) had GH. These patients had a later onset of independent walking (17 vs. 15 months, p < 0.01), a higher proportion of motor stereotypies (65.6 vs. 27.9%, p < 0.01), a lower mean total score in the parental-reported Generic Core Scale of Pediatric Quality of Life Inventory 4.0 (71 vs. 76 points, p 0.03), and a higher mean total score in the Calibrated Severity Score of Autism Diagnostic Observation Schedule version 2 at diagnosis (6 vs. 5 points, p 0.02) compared to the group without GH. Conclusion: Hypotonia is associated with other motor abnormalities and could be an early marker for higher autistic symptom severity and lower quality of life in young children with ASD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d9328a97cf0d01e4ecb6a3e2d23a46f https://doi.org/10.1007/s00431-021-04038-7 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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