Synthesis of biologically active fluorescent phorbol esters

Autor: Marie-Josèphe Brienne, Liliane Lacombe, Phuong Lan Tran, J. Malthête
Rok vydání: 1986
Předmět:
Zdroj: Tetrahedron Letters. 27:2371-2374
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84532-3
Popis: Pure fluorescent derivatives of 12-O-tetradecanoyl phorbol-13-O-acetate (TPA), labeled in the tetradecanoyl chain, are synthesized by two ways: 1) from both enantiomers of β-N-dansylaminotetradecanoic acid which requires the resolution of the (±) β-aminoacid precursor; 2) from an achiral fluorescent chain derived from 3-azatetradecanoic acid. The new phorbol derivatives retain the main biological activity of TPA.
Databáze: OpenAIRE