Synthesis of biologically active fluorescent phorbol esters
Autor: | Marie-Josèphe Brienne, Liliane Lacombe, Phuong Lan Tran, J. Malthête |
---|---|
Rok vydání: | 1986 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 27:2371-2374 |
ISSN: | 0040-4039 |
DOI: | 10.1016/s0040-4039(00)84532-3 |
Popis: | Pure fluorescent derivatives of 12-O-tetradecanoyl phorbol-13-O-acetate (TPA), labeled in the tetradecanoyl chain, are synthesized by two ways: 1) from both enantiomers of β-N-dansylaminotetradecanoic acid which requires the resolution of the (±) β-aminoacid precursor; 2) from an achiral fluorescent chain derived from 3-azatetradecanoic acid. The new phorbol derivatives retain the main biological activity of TPA. |
Databáze: | OpenAIRE |
Externí odkaz: |