Aripiprazole for the treatment of psychotic symptoms in patients with dementia with Lewy bodies: a case series
| Autor: | Yuka Sugawara Kikuchi, Tetsuo Shimizu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
End point business.industry Dementia with Lewy bodies Clinical Dementia Rating medicine.disease Neuropsychiatric inventory 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders Brief Psychiatric Rating Scale medicine Dementia Aripiprazole In patient business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuropsychiatric Disease and Treatment. 15:543-547 |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s189050 |
| Popis: | Purpose The core features of dementia with Lewy bodies (DLB) are cognitive fluctuations, visual hallucinations, and parkinsonian symptoms. Although there have been several reports on the efficacy of treatments for psychotic symptoms in patients with DLB, little is known regarding the treatment effects of aripiprazole. The aim of this study was to evaluate the efficacy and safety of aripiprazole for the treatment of psychotic symptoms in patients with DLB. Patients and methods We employed a 10-week, open-label study design with 11 patients who met the criteria for DLB. The patients had previously experienced persistent or intermittent delusions, hallucinations, or both for at least 1 month. Aripiprazole was initiated at a low dose (3 or 6 mg/day) and titrated to higher doses at 2-week intervals or more rapidly, as needed. The Neuropsychiatric Inventory (NPI), Brief Psychiatric Rating Scale (BPRS), and Clinical Global Impression-Severity (CGI-S) were administered at baseline and 1, 2, 4, 8, and 10 weeks later. The Simpson-Angus Scale (SAS), Clinical Dementia Rating (CDR), and Mini-Mental State Examination (MMSE) Scale were evaluated at baseline and at week 10. The NPI, CGI-S, and BPRS scores were compared between the baseline and each assessment point and between each assessment point and the one before assessment point. The SAS, CDR, and MMSE scores were compared between the baseline and the end point. Results The mean NPI and BPRS scores improved until the fourth week; they significantly decreased at each assessment point compared to the previous one. Afterward, improvements slowed and continued without significant decrease. The median SAS scores significantly decreased at the end point compared to the baseline (P |
| Databáze: | OpenAIRE |
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