Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease
Autor: | Michael S. Middleton, Kathryn J. Fowler, Kris V. Kowdley, James Tonascia, Mark L. Van Natta, Arun J. Sanyal, Cynthia Behling, Adrija Mamidipalli, Wei Shen, Joel E. Lavine, Michael A. Ohliger, Tanya Wolfson, Claude B. Sirlin, Andrew T. Trout, Daniela S. Allende, Rohit Loomba, Jonathan Hooker, Shetal N. Shah, Anthony Gamst, Adina Alazraki, Mustafa R. Bashir, Jeffrey B. Schwimmer |
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Rok vydání: | 2018 |
Předmět: |
Nonalcoholic steatohepatitis
medicine.medical_specialty Univariate analysis business.industry Proton density fat fraction medicine.disease Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nash crn Internal medicine Nonalcoholic fatty liver disease Medicine Liver iron Radiology Nuclear Medicine and imaging In patient Steatosis business |
Zdroj: | Journal of Magnetic Resonance Imaging. 49:1456-1466 |
ISSN: | 1053-1807 |
Popis: | Author(s): Bashir, Mustafa R; Wolfson, Tanya; Gamst, Anthony C; Fowler, Kathryn J; Ohliger, Michael; Shah, Shetal N; Alazraki, Adina; Trout, Andrew T; Behling, Cynthia; Allende, Daniela S; Loomba, Rohit; Sanyal, Arun; Schwimmer, Jeffrey; Lavine, Joel E; Shen, Wei; Tonascia, James; Van Natta, Mark L; Mamidipalli, Adrija; Hooker, Jonathan; Kowdley, Kris V; Middleton, Michael S; Sirlin, Claude B; NASH Clinical Research Network (NASH CRN) | Abstract: BackgroundThe liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates.PurposeTo identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD).Study typeRetrospective analysis of prospectively acquired data.PopulationBaseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials.Field strength1.5T and 3T; chemical-shift encoded multiecho gradient echo.AssessmentCorrelation between liver proton density fat fraction and R2*; assessment for demographic, metabolic, laboratory, MRI-derived, and histological covariates of liver R2*.Statistical testsPearson's and Spearman's correlations; univariate analysis; gradient boosting machines (GBM) multivariable machine-learning method.ResultsHepatic proton density fat fraction (PDFF) was the most strongly correlated covariate for R2* at both 1.5T (r = 0.652, P l 0.0001) and at 3T (r = 0.586, P l 0.0001). In the GBM analysis, hepatic PDFF was the most influential covariate for hepatic R2*, with relative influences (RIs) of 61.3% at 1.5T and 47.5% at 3T; less influential covariates had RIs of up to 11.5% at 1.5T and 16.7% at 3T. Nonhepatocellular iron was weakly associated with R2* at 3T only (RI 6.7%), and hepatocellular iron was not associated with R2* at either field strength.Data conclusionHepatic PDFF is the most influential covariate for R2* at both 1.5T and 3T; nonhepatocellular iron deposition is weakly associated with liver R2* at 3T only.Level of evidence4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1456-1466. |
Databáze: | OpenAIRE |
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