Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination
| Autor: | Mayumi Iwasa, Kenji Inoue, Hua Piao, Goji Tomita, Kyoko Ishida |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure genetic structures business.industry Glaucoma Timolol Ocular hypertension medicine.disease eye diseases 03 medical and health sciences Ophthalmology chemistry.chemical_compound 0302 clinical medicine Blood pressure chemistry 030221 ophthalmology & optometry medicine Carteolol sense organs Latanoprost Latanoprost/timolol business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical Ophthalmology. 14:1207-1214 |
| ISSN: | 1177-5483 |
| DOI: | 10.2147/opth.s240425 |
| Popis: | Purpose To investigate the short-term intraocular pressure-lowering efficacy and safety of switching from a fixed combination of latanoprost/timolol to a fixed combination of latanoprost/carteolol. Patients and Methods The subjects were 30 eyes of 30 adult patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who were using a latanoprost-/timolol-fixed combination with insufficient intraocular pressure-lowering efficacy or adverse reactions. The subjects were switched from once-daily latanoprost/timolol to once-daily latanoprost/carteolol with no washout interval. Intraocular pressure, tear film break-up time, corneal epithelial defects, conjunctival hyperemia, blood pressure, and pulse rate were measured and compared before and 1 and 3 months after switching. Patients were monitored for adverse reactions at each visit, and dropouts were recorded. Results The mean intraocular pressure at 1 month (15.9±3.1 mmHg) and 3 months (16.3±3.8 mmHg) was not significantly different from that at baseline (16.1±3.1 mmHg). The tear film break-up time and corneal epithelial defects were significantly improved after switching (p |
| Databáze: | OpenAIRE |
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