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Depression is a common neuropsychiatric disorder in women, particularly among women with HIV infection. The association of adiposity with depressive symptoms in adult women is unclear. We evaluated the cross-sectional association of depressive symptoms measured using the Centre for Epidemiological Studies Depression scale (CES-D) score, with anthropometric (body mass index, waist-to-hip ratio and waist circumference) and metabolic (adipokines: leptin, total adiponectin, and high molecular weight adiponectin) adiposity measures. This was accomplished in HIV-infected or at-risk HIV-uninfected participants at the Brooklyn, New York site of the Women’s Interagency HIV Study. Participants (250 HIV+, 107 HIV-; average age 38.9 years), with measured levels of leptin and adiponectins were included. Adiposity measures were considered as continuous and categorical variables. A clinically relevant depressive symptom burden was defined as CES-D > 16. Spearman correlations, T-tests, multivariable linear and logistic regression models, and Receiver Operating Characteristic tests were used. Neither anthropometric nor metabolic adiposity measures were associated with depressive symptoms in this sample. To our knowledge, this is the first report on the association between depressive symptoms and anthropometric and metabolic adiposity measures in HIV-infected or HIV-uninfected women. Despite null findings, these results contribute to our understanding of adiposity-associated risk related to neuropsychiatric outcomes in at risk women. |
