Nuclear protein in testis midline carcinoma in a Turkish boy: a case report
| Autor: | Demir Kursat Yildiz, Yonca Anik, Ugur Demirsoy, Funda Corapcioglu, Büşra Yaprak Bayrak, Christopher A. French |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty business.industry Turkish Geography Planning and Development Management Monitoring Policy and Law medicine.disease language.human_language 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Carcinoma medicine language Nuclear protein business |
| Zdroj: | Asian Biomedicine. 14:203-208 |
| ISSN: | 1875-855X |
| Popis: | Background Nuclear protein in testis (NUT) midline carcinoma (NMC) is an undifferentiated carcinoma, usually localized to the midline and presenting a translocation in the gene for bromodomain containing protein 4. Here, we report a rare case of NMC in an 8-year-old Turkish boy. Case report There were masses in the lung, liver, and iliac wing representing metastases. Abdominal lymph node sampling revealed epithelial tumor infiltration with cellular pleomorphism. Immunohistochemistry was strongly positive for cytokeratin and epithelial membrane antigen protein. Because of undifferentiated carcinoma morphology, the tumor was considered to be a NMC. Immunoreactivity with antibodies to NUT and the presence of NUT clarified by fluorescence in situ hybridization (FISH) supported the diagnosis. Despite initial response to chemotherapy, the patient died 7 months after the diagnosis. Conclusions Immunoreactivity for NUT antibodies along with a dual-color FISH and karyotype analysis was suggestive for diagnosis of NMC. In differential diagnosis of undifferentiated carcinomas that occur particularly at midline localization, NMC should be considered. |
| Databáze: | OpenAIRE |
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