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Leis Kamil, Mazur Ewelina, Szyperski Paweł, Kaczor Patryk, Kolan Michalina, Wiśniewski Bartłomiej, Jabłońska Magdalena, Kulczyńska Aleksandra, Baska Aleksandra, Kazik Jakub, Bojczuk Daria, Grzelakowska Klaudyna, Kałużny Krystian, Gałązka Przemysław. Metallo-Beta-Lactamases: NDM. Journal of Education, Health and Sport. 2019;9(6):27-40. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3236053 http://ojs.ukw.edu.pl/index.php/johs/article/view/6977 https://pbn.nauka.gov.pl/sedno-webapp/works/914931 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.05.2019. Revised: 25.05.2019. Accepted: 31.05.2019. METALLO-BETA-LACTAMASES: NDM Kamil Leis1*, Ewelina Mazur1, Paweł Szyperski1, Patryk Kaczor1, Michalina Kolan1, Bartłomiej Wiśniewski1, Magdalena Jabłońska1, Aleksandra Kulczyńska1, Aleksandra Baska1, Jakub Kazik1, Daria Bojczuk1, Klaudyna Grzelakowska1, Krystian Kałużny2, Przemysław Gałązka3 Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-090 Bydgoszcz, Poland Chair and Clinic of Rehabilitation, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-067 Bydgoszcz, Poland Department of General and Oncological Paediatric Surgery, Antoni Jurasz University Hospital No. 1 in Bydgoszcz, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-090 Bydgoszcz, Poland Corresponding author- Kamil Leis- kamil.leis13@gmail.com Abstract: New Delhi, an enzyme belonging to the Metallo-beta-lactamases and Carbapenemases group, is most commonly found in Klebsiella pneumoniae and Escherichia coli. It determines these bacteria resistance to the majority of known antibiotics. NDM-1 was discovered in 2008 in a man treated in New Delhi for E. coli infection. Since the first appearance, 17 subtypes of this enzyme have been discovered. Its occurrence has been reported in Europe (Great Britain, France, Belgium - where even a national alert has been issued) as well as in the United States and in Africa. Most cases of New Delhi enzyme bacterial infections are reported in India or in people who have traveled to this country. There is no treatment method described so far. Therapy is based on antibiotic susceptibility test results. Colistin shows the highest effectiveness against NDM. There are also tests suggesting that Isomargololone and Nimbolide may be effective in most cases of NDM infection. Key words: metallo beta lactamases, New Delhi, carbapenemes, E. coli |
