Development of radiogallium–ethylenecysteamine cysteine complex as a possible renal imaging agent
| Autor: | Mohammad Reza Khoshdel, Hassan Yousefnia, Ali Rahiminejad, Amir Reza Jalilian, Samaneh Zolghadri, Fatemeh Bolourinovin |
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| Rok vydání: | 2010 |
| Předmět: |
Octanol
Kidney Biodistribution Chromatography Chemistry Health Toxicology and Mutagenesis medicine.medical_treatment Public Health Environmental and Occupational Health Pollution Analytical Chemistry Excretion Partition coefficient chemistry.chemical_compound medicine.anatomical_structure Nuclear Energy and Engineering medicine Radiology Nuclear Medicine and imaging Specific activity Saline Spectroscopy Cysteine |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 284:49-54 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-010-0459-y |
| Popis: | [67Ga]-ethylenecysteamine cysteine ([67Ga]ECC) was prepared using freshly prepared [67Ga]GaCl3 and ethylenecysteamine cysteine (ECC) for 30 min at 90 °C (radiochemical purity ≈97 ± 0.88% ITLC, specific activity: 210 ± 5 GBq/mM). Stability of the complex was checked in human serum for 24 h at 37 °C. Partition co-efficient of the tracer in octanol:saline mixture was determined (log P; 0.8). The biodistribution of the radiolabeled compound in vital organs of wild-type rats were compared with that of free Ga3+ cation up to 48 h. Initial biodistribution results showed significant kidney excretion of the tracer comparable to that of homologous 99mTc compound. |
| Databáze: | OpenAIRE |
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