Plasma renin activity levels influence the effect of converting enzyme inhibitors in preserving renal function in hypertension
| Autor: | Mercedes Migliorini, Ramiro A. Sanchez, Carlos Giannone, Agustin J. Ramirez |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Kidney Physiology business.industry Renal function Cilazapril urologic and male genital diseases medicine.disease Essential hypertension Plasma renin activity Endocrinology Blood pressure medicine.anatomical_structure Nifedipine Diabetes mellitus Internal medicine Internal Medicine medicine Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Hypertension. 14:1025 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/00004872-199608000-00014 |
| Popis: | OBJECTIVE: To study the effect of treatment with cilazapril versus nifedipine on the glomerular filtration rate (GFR), microalbumin excretion rate (mu Alb) and baseline plasma renin activity (PRA) levels in non-diabetic or diabetic essential hypertension. DESIGN AND METHODS: Thirty-four moderate essential hypertensives and thirty-two type II diabetic hypertensives with currently normal renal function completed the study, receiving treatment with a converting enzyme inhibitor (CEI, 5-10 mg/day cilazapril) or a non-CEI (20-40 mg slow-release nifedipine three times a day) during a 12-month controlled follow-up study. RESULTS: Either treatment induced a similar reduction in blood pressure. Patients with PRA > 3 ng/ml per h treated with cilazapril showed a proportional increase in GFR, whereas in those treated with a non-CEI there was a decline in GFR after 8 and 12 months. Only diabetic patients treated with cilazapril showed a mu Alb reduction associated with a stable GFR. CONCLUSION: PRA predicts the effect of CEI preserving renal function in essential and diabetic hypertension. |
| Databáze: | OpenAIRE |
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