PRECOCIOUS INCREASE OF SUCRASE ACTIVITY IN THE INTESTINE SMALL OF SUCKLING BY CARBOHYDRATES: SRESSORY EFFECT OF SUGAR INDUCED DIARRHEA
| Autor: | Judy Grimes, Toshinao Goda, Otakar Koldovsk, John Edmond, Sergio Bustamante |
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| Rok vydání: | 1984 |
| Předmět: | |
| Zdroj: | Pediatric Research. 18:203A-203A |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198404001-00658 |
| Popis: | Increased intake of sucrose (S) is followed in adult and suckling rats by an increase of sucrase activity (SA). This study analyzes the increase of SA in suckling rats evoked by the early feeding of S and other sugars. Ten-day-old rats, removed from their mothers, were gavage fed for 4 days a low carbohydrate milk formula (MF), [10.8% fat, 8% protein, 1.4% carbohydrate-w/v], with or without addition(s) of lactose or fructose (FR), both 13%. Feeding the MF with FR led to diarrhea and an increase of SA. Gastric evacuation of MF with S or FR was significantly slower than MF low in carbohydrates or with lactose. When MF with S or FR were placed directly into the ligated jejunoileum in situ, net water absorption was decreased. Ten-day-old rats kept with the mother, and receiving twice daily 0.5 ml of 5% mannitol in water developed diarrhea within one day, and a marked increase of SA which gradually decreased after the 2nd day of mannitol feeding. Serum corticosterone level was highly increased 8 hrs after the initiation of the mannitol feeding or MF with S or FR. Our experiments thus explain the role of adrenals in increase of SA in sucklings. In contrast to adult rats, increase of SA in suckling rats by dietary sugars is mainly due to the stress caused by diarrhea that is evoked by undigested and/or unabsorbed amount of sugars. |
| Databáze: | OpenAIRE |
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