A Comparison of Directional Atherectomy with Coronary Angioplasty in Patients with Coronary Artery Disease

Autor:	Stephen G. Ellis, Eric J. Topol, Tomoaki Hinohara, Gordon Keeler, Kerry L. Lee, Ferdinand Leya, Cass A. Pinkerton, Spencer B. King, Jeffrey M. Isner, Patrick W. Serruys, Ronald Masden, Lisa G. Berdan, Martin B. Leon, Patrick L. Whitlow, Berthold Höfling, David R. Holmes, Daniel B. Mark, Charles A. Simonton, David O. Williams, Robert M. Califf
Rok vydání:	1993
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment General Medicine medicine.disease Balloon Coronary artery disease Atherectomy Stenosis Restenosis Angioplasty Internal medicine Cardiology medicine Myocardial infarction Radiology Prospective cohort study business
Zdroj:	New England Journal of Medicine. 329:221-227
ISSN:	1533-4406 0028-4793
DOI:	10.1056/nejm199307223290401
Popis:	Background Directional coronary atherectomy is a new technique of coronary revascularization by which atherosclerotic plaque is excised and retrieved from target lesions. With respect to the rate of restenosis and clinical outcomes, it is not known how this procedure compares with balloon angioplasty, which relies on dilation of the plaque and vessel wall. We compared the rate of restenosis after angioplasty with that after atherectomy. Methods At 35 sites in the United States and Europe, 1012 patients were randomly assigned to either atherectomy (512 patients) or angioplasty (500 patients). The patients underwent coronary angiography at base line and again after six months; the paired angiograms were quantitatively assessed at one laboratory by investigators unaware of the treatment assignments. Results Stenosis was reduced to 50 percent or less more often with atherectomy than with angioplasty (89 percent vs. 80 percent, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d5cae61e1212b4ae99e9dea41e5dc49 https://doi.org/10.1056/nejm199307223290401 Zobrazit plný text záznamu