| Autor: |
Li Zhang, Hao Niu, Ping Yang, Jie Ma, Bao-Ying Yuan, Zhao-Chong Zeng, Zuo-Lin Xiang |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
BackgroundEarly screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.MethodsThe expression levels of lnc34a in serum samples from 157 HCC patients were detected by quantitative real-time PCR. Univariate analysis and multivariate analysis were performed to determine statistically significant variables.ResultsExpression levels of lnc34a in serum from HCC patients with bone metastasis were significantly higher than those without bone metastasis. And high expression of lnc34a, vascular invasion and BCLC stage were associated with bone metastasis by analysis. Moreover, lnc34a expression was specifically associated with bone metastasis rather than lung or lymph node metastasis in HCC.Conclusions High serum lnc34a expression was a independent risk factor for developing bone metastasis in HCC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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